Keyword         Theme  


  • Interspecies differences in the cytochrome P450 activity of hepatocytes exposed to PLGA and silica nanoparticles: an in vitro and in vivo investigation.Cornu R,  Rougier N,  Pellequer Y, Lamprecht A, Hamon P, Li R, Beduneau A, Martin H
    Nanoscale, Mar 2018
  • Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.Neuhaus W,  Piontek A,  Protze J,  Eichner M, Mahringer A, Subileau EA, Lee IM, Schulzke JD, Krause G, Piontek J
    Biomaterials, Feb 2018
  • Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes? model.Parmentier Y,  Pothier C,  Hewitt N,  Vincent L, Caradec F, Liu J, Lin F, Trancart MM, Guillet F, Bouaita B, Chesne C, Walther B
    Xenobiotica, Jan 2018


  • GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding.Zabela V,  Hettich T,  Schlotterbeck G,  Wimmer L, Mihovilovic MD, Guillet F, Bouaita B, Shevchenko B, Hamburger M, Oufir M.
    J Chromatogr B Analyt Technol Biomed Life Sci, Dec 2017
  • MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.Gill P, Bhattacharyya S, McCullough S, Letzig L, Mishra PJ, Luo C, Dweep H, James L
    Sci Rep, Sep 2017
  • Thymoquinone prevents endoplasmic reticulum stress and mitochondria-induced apoptosis in a rat model of partial hepatic warm ischemia reperfusion.Bouhlel A,  Ben Mosbah I,  Hadj Abdallah N,  Ribault C
    Biomed Pharmacother, Aug 2017
  • An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation.Compagnon P,  Levesque E,  Hentati H,  Disabato M
    Transplantation., Aug 2017
  • ?2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine.Mayati A,  Moreau A,  Denizot C,  Stieger B,  Parmentier Y,  Fardel O
    Eur J Pharm Sci, Jun 2017
  • Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples.Richter LHJ,  Flockerzi V,  Maurer HH,  Meyer MR
    J Pharm Biomed Anal. , May 2017


  • Stable overexpression of the constitutive androstane receptor reduces the requirement for culture with dimethyl sulfoxide for high drug metabolism in HepaRG cells.Van der Mark VA,  de Waart DR,  Shevchenko V,  Oude Elferink RP
    Drug Metab Dispos, Oct 2016
  • Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.Burbank, Burban, Sharanek, Weaver, Guguen-Guillouzo, Guillouzo.
    Drug Metab Dispos, Aug 2016
  • Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model.Parmentier Y, Pothier C , Delmas A , Caradec F,Trancart MM, Guillet F, Bouaita B, Chesne C, Brian Houston J, Walther B.
    Xenobiotica, Aug 2016
  • Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines.van Wenum M,  Adam AA,  Hakvoort T, Hendriks EJ, Shevchenko V, van Gulik TM, Chamuleau RA, Hoekstra R.
    Int J Biol Sci., Jul 2016
  • Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.Sharanek A, Burban A, Burbank M, Le Guevel R, Li R, Guillouzo A, Guguen Guillouzo
    scientific reports, May 2016
  • In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidenceAtes G, Raitano G, Heymans A, Van Bossuyt M, Vanparys P, Mertens B, Chesne C, Roncaglioni A, Milushev D, Benfenati E, Rogiers V, Doktorova TY
    Mutagenesis, Mar 2016


  • First Training on Alternatives to Animal Experimentation in TunisiaMbarek S, Pellevoisin C, Chesné C, Busquet F, Souilem O
    Altex, Nov 2015
  • Suitability of skin integrity tests for dermal absorption studies in vitroGuth K, Schäfer-Korting M, Fabian E, Landsiedel R, van Ravenzwaay B
    Tox in Vitro, Feb 2015
  • Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes.Bachour-El Azzi P, Sharanek A, Burban A, Li R, Le Guével R, Abdel-Razzak Z, Stieger B, Guguen-Guillouzo C, Guillouzo A
    Toxicol Sci., Feb 2015


  • Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptorKanno Y, Tanuma N, Yatsu T, Li W, Koike K, Inouye Y
    PRP, Nov 2014
  • Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 CellsNovotna A, Krasulová K, Bartonková I, Korhonová M, Bachleda P, Anzenbacher P, Dvorák Z
    Plos One, Oct 2014
  • Gold(I) Complexes of 9-Deazahypoxanthine as Selective Antitumor and Anti-Inflammatory AgentsVanco J, Gáliková J, Ho?ek J, Dvo?ák Z, Paráková L, Trávní?ek Z
    Plos One, Oct 2014
  • Utility of cryopreserved hepatocytes suspended in serum to predict hepatic clearance in dogs and monkeysShibata Y, Kuze J, Chiba M
    Drug Metab Pharmacokinet, Sep 2014
  • Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like CellsKondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T
    Plos One, Aug 2014
  • Omeprazole and Lansoprazole Enantiomers Induce CYP3A4 in Human Hepatocytes and Cell Lines via Glucocorticoid Receptor and Pregnane X Receptor AxisNovotna A, Dvorak Z
    Plos One, Aug 2014
  • Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell LinesNovotna A, Srovnalova A, Svecarova M, Korhonova M, Bartonkova I, Dvorak Z
    Plos One, Jul 2014
  • Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon ReceptorNovotna A, Korhonova M, Bartonkova I, Soshilov AA, Denison MS, Bogdanova K, Kolar M, Bednar P, Dvorak Z
    Plos One, Jul 2014
  • Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytesSugiyama Y, Yamazaki K, Kusaka-Kikushima A, Nakahigashi K, Hagiwara H, Miyachi Y
    Open Bio, Jun 2014
  • Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthicEilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D
    Toxicokinetics and Metabolism, Mar 2014
  • A Bioinformatics Approach Identifies Signal Transducer and Activator of Transcription-3 and Checkpoint Kinase 1 as Upstream Regulators of Kidney Injury Molecule-1 after Kidney InjuryKumar Ajay A, Kim T-M, Vaidya VS
    JASN, Jan 2014
  • Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro ModelsNovakova I, Subileau EA, Toegel S, Gruber D, Lachmann B, Urban E, Chesne C, Noe CR, Neuhaus W
    Plos One, Jan 2014


  • Effects of the Amino Acid Constituents of Microcystin Variants on Cytotoxicity to Primary Cultured Rat HepatocytesShimizu K, Sano T, Kubota R, Kobayashi N, Tahara M, Obama T, Sugimoto N, Nishimura T, Ikarashi Y
    Toxins, Dec 2013
  • Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian HepatocytesHayward AS, Eissa AM, Maltman DJ, Sano N, Przyborski SA, Cameron NR
    BioMacromolecules, Nov 2013
  • Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver CellsVrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T
    Plos One, Sep 2013
  • Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C VirusHelle F, Brochot E, Fournier C, Descamps V, Izquierdo L, Hoffmann TW, Morel V, Herpe YE, Bengrine A, Belouzard S, Wychowski C, Dubuisson J, Francois C, Regimbeau JM, Castelain S, Duverlie G
    Plos One, Aug 2013
  • An In Vitro Expansion System for Generation of Human iPS Cell-Derived Hepatic Progenitor-Like Cells Exhibiting a Bipotent Differentiation PotentialYanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A
    Plos One, Jul 2013
  • Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signalingChou WC, Takeo M, Rabbani P, Hu H, Lee W, Chung YR, Carucci J, Overbeek P, Ito M
    Nat Med, Jul 2013
  • Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174TKamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z
    Toxicol Lett, Apr 2013


  • Three-Dimensional Expansion Using Plasma-Medium Gel with Fragmin/Protamine Nanoparticles and FGF-2 to Stimulate Adipose-Derived Stromal Cells and Bone Marrow-Derived Mesenchymal Stem CellsKishimoto S, Ishihara M, Mori Y, Takikawa M, Sumi Y, Nakamura S, Sato T, Kiyosawa T
    BioResearch, Dec 2012
  • Synthesis of New N,N'-Bis(5-arylidene-4-oxo- 4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological EvaluationCoulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP
    Scientia Pharmaceutica, Sep 2012
  • Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane PartnersSage J, Leblanc-Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, Kurfurst R, Brömme D, Lalmanach G, Lecaille F
    Plos One, Aug 2012
  • Defining new criteria for selection of cell-based intestinal models using publicly available databasesChristensen J, El-Gebali S, Natoli M, Sengstag T, Delorenzi M, Bentz S, Bouzourene H, Rumbo M, Felsani A, Siissalo S, Hirvonen J, Vila MR, Saletti P, Aguet M, Anderle P
    BMC Genomics, Jun 2012
  • Effect of Direction (Epidermis-To-Dermis and Dermis-To-Epidermis) on the Permeation of Several chemical Compounds through full-thickness Skin and Stripped SkinOshizaka T, Todo H, Sugibayashi K
    Pharm Res, May 2012
  • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxinsGerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA
    Cell Bio, Apr 2012
  • In vitro Evaluation of the Interaction Potential of Irosustat with Drug Metabolizing EnzymesVentura V, Solà J, Peraire C, Brée F, Obach R
    Drug Metab Dis, Mar 2012
  • A possible regulation mechanism of water content in human stratum corneum via intercellular lipid matrixNakazama H, Ohta N, Hatta I
    Chem. & Physics, Feb 2012
  • Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer AetiologyPaget V, Lechevrel M, André V, Goff JL, Pottier D, Billet S, Garçon G, Shirali P, Sichel F
    Plos One, Feb 2012
  • Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesPavek P, Stejskalova L, Krausova L, Bitman M, Vrzal R, Dvorak Z
    Frontiers in Pharm., Jan 2012


  • Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice Brezillon N, Brunelle MN, Massinet H, Giang E, Lamant C, DaSilva L, Berissi S, Belghiti J, Hannoun L, Puerstinger G, Wimmer E, Neyts J, Hantz O, Soussan P, Morosan S, Kremsdorf D
    PlosOne, Dec 2011
  • Human scalp permeability to the chemical warfare agent VXRolland P, Bolzinger MA, Cruz C, Briançon S, Josse D
    Tox in Vitro, Dec 2011
  • Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneKrausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P
    Biochem Pharmacol, Dec 2011
  • Comparison of several reconstructed cultured human skin models by microscopic observation: their usefulness as an alternative membrane for skin in drug permeation experimentsKano S, Tanuma N, Yatsu T, Li W, Koike K & Inouye Y
    AATEX, Nov 2011
  • The presence of N?-(Carboxymethyl) lysine in the human epidermisKawabata K, Yoshikawa H, Saruwatari K, Akazawa Y, Inoue T, Kuze T, Sayo T, Uchida N, Sugiyama Y
    BBA, Oct 2011
  • Fully automated microinjection system for Xenopus laevis oocytes with integrated sorting and collection.Graf SF, Madigou T, Li R, Chesné C, Stemmer A, Knapp HF
    J. of the Association for Laboratory Automation, Jun 2011
  • Comparative Gene Expression Profiles Induced by PPAR? and PPAR?/? Agonists in Human HepatocyteRogue A, Lambert C, Jossé R, Antherieu S, Spire C, Claude N, Guillouzo A
    Plos One, Apr 2011
  • CYP3A5 genotype does not influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipientsPicard N, Rouguieg-Malki K, Kamar N, Rostaing L, Marquet P
    Transplantation, Mar 2011
  • Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytesBadolo L, Trancart MM, Gustavsson L, Chesné C
    Chemico Biological Int., Feb 2011
  • Marine Natural Meroterpenes: Synthesis and Antiproliferative ActivitySimon-Levert A, Menniti C, Soulère L, Genevière AM, Barthomeuf C, Banaigs B, Witczak A
    Marine Drug, Feb 2011


  • Prediction of Clinical CYP3A4 induction using cryopreserved human hepatocytesKaneko A, Kato M, Endo C, Nakano K, Ishigai M, Takeda K
    Xenobiotica, Dec 2010
  • Insulin Induces REDD1 Expression through Hypoxiainducible Factor 1 Activation in AdipocytesRegazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S
    J Biol Chem, Nov 2010
  • Liverbeads?: a practical and relevant in vitro model for gene induction investigationsAl Khansa I, Blanck O, Guillouzo A, Bars R
    Drug Metab Dis, Sep 2010
  • Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like CellsRoelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM
    Plos One, Aug 2010
  • A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver TissuesHart N, Li Y, Nakamoto K, Subileau EA, Steen D, Zhong XB
    Drug Metab Dis, Jun 2010
  • Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiationHamidouche Z, Fromigué O, Ringe J, Häupl T, Marie PJ
    BMC Cell Bio, Jun 2010
  • In Vivo Identification of Solar Radiation-Responsive Gene Network: Role of the p38 Stress-Dependent Kinase Mouchet N, Adamski H, Bouvet R, Corre S, Courbebaisse Y, Watier E, Mosser J, Chesné C, Galibert MD
    Plos One, May 2010
  • Controlling integrin specificity and stem cell differentiation in 2-D and 3-D environments through regulation of fibronectin domain stabilityMartino MM, Mochizuki M, Rothenfluh DA, Rempel SA, Hubbell JA, Barker TH
    Biomaterials, Feb 2010