Hepatocytes: Resources




  • Stable overexpression of the constitutive androstane receptor reduces the requirement for culture with dimethyl sulfoxide for high drug metabolism in HepaRG cells.Van der Mark VA,  de Waart DR,  Shevchenko V,  Oude Elferink RP
    Drug Metab Dispos, Oct 2016
  • Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines.van Wenum M,  Adam AA,  Hakvoort T, Hendriks EJ, Shevchenko V, van Gulik TM, Chamuleau RA, Hoekstra R.
    Int J Biol Sci., Jul 2016


  • Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes.Bachour-El Azzi P, Sharanek A, Burban A, Li R, Le Guével R, Abdel-Razzak Z, Stieger B, Guguen-Guillouzo C, Guillouzo A
    Toxicol Sci., Feb 2015


  • Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptorKanno Y, Tanuma N, Yatsu T, Li W, Koike K, Inouye Y
    PRP, Nov 2014
  • Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 CellsNovotna A, Krasulová K, Bartonková I, Korhonová M, Bachleda P, Anzenbacher P, Dvorák Z
    Plos One, Oct 2014
  • Gold(I) Complexes of 9-Deazahypoxanthine as Selective Antitumor and Anti-Inflammatory AgentsVanco J, Gáliková J, Ho?ek J, Dvo?ák Z, Paráková L, Trávní?ek Z
    Plos One, Oct 2014
  • Utility of cryopreserved hepatocytes suspended in serum to predict hepatic clearance in dogs and monkeysShibata Y, Kuze J, Chiba M
    Drug Metab Pharmacokinet, Sep 2014
  • Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like CellsKondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T
    Plos One, Aug 2014
  • Omeprazole and Lansoprazole Enantiomers Induce CYP3A4 in Human Hepatocytes and Cell Lines via Glucocorticoid Receptor and Pregnane X Receptor AxisNovotna A, Dvorak Z
    Plos One, Aug 2014
  • Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell LinesNovotna A, Srovnalova A, Svecarova M, Korhonova M, Bartonkova I, Dvorak Z
    Plos One, Jul 2014
  • Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon ReceptorNovotna A, Korhonova M, Bartonkova I, Soshilov AA, Denison MS, Bogdanova K, Kolar M, Bednar P, Dvorak Z
    Plos One, Jul 2014


  • Effects of the Amino Acid Constituents of Microcystin Variants on Cytotoxicity to Primary Cultured Rat HepatocytesShimizu K, Sano T, Kubota R, Kobayashi N, Tahara M, Obama T, Sugimoto N, Nishimura T, Ikarashi Y
    Toxins, Dec 2013
  • Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian HepatocytesHayward AS, Eissa AM, Maltman DJ, Sano N, Przyborski SA, Cameron NR
    BioMacromolecules, Nov 2013
  • Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver CellsVrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T
    Plos One, Sep 2013
  • Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C VirusHelle F, Brochot E, Fournier C, Descamps V, Izquierdo L, Hoffmann TW, Morel V, Herpe YE, Bengrine A, Belouzard S, Wychowski C, Dubuisson J, Francois C, Regimbeau JM, Castelain S, Duverlie G
    Plos One, Aug 2013
  • An In Vitro Expansion System for Generation of Human iPS Cell-Derived Hepatic Progenitor-Like Cells Exhibiting a Bipotent Differentiation PotentialYanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A
    Plos One, Jul 2013
  • Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174TKamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z
    Toxicol Lett, Apr 2013


  • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxinsGerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA
    Cell Bio, Apr 2012
  • In vitro Evaluation of the Interaction Potential of Irosustat with Drug Metabolizing EnzymesVentura V, Solŕ J, Peraire C, Brée F, Obach R
    Drug Metab Dis, Mar 2012
  • Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesPavek P, Stejskalova L, Krausova L, Bitman M, Vrzal R, Dvorak Z
    Frontiers in Pharm., Jan 2012


  • Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice Brezillon N, Brunelle MN, Massinet H, Giang E, Lamant C, DaSilva L, Berissi S, Belghiti J, Hannoun L, Puerstinger G, Wimmer E, Neyts J, Hantz O, Soussan P, Morosan S, Kremsdorf D
    PlosOne, Dec 2011
  • Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneKrausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P
    Biochem Pharmacol, Dec 2011
  • Comparative Gene Expression Profiles Induced by PPAR? and PPAR?/? Agonists in Human HepatocyteRogue A, Lambert C, Jossé R, Antherieu S, Spire C, Claude N, Guillouzo A
    Plos One, Apr 2011
  • Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytesBadolo L, Trancart MM, Gustavsson L, Chesné C
    Chemico Biological Int., Feb 2011


  • Prediction of Clinical CYP3A4 induction using cryopreserved human hepatocytesKaneko A, Kato M, Endo C, Nakano K, Ishigai M, Takeda K
    Xenobiotica, Dec 2010
  • Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like CellsRoelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM
    Plos One, Aug 2010
  • A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver TissuesHart N, Li Y, Nakamoto K, Subileau EA, Steen D, Zhong XB
    Drug Metab Dis, Jun 2010



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Hepatocytes_sandwich_collagene_48hFresh plated hepatocytes
↑ Hepatocytes in collagen sandwich after 48h/ Fresh plated hepatocytes
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↑ Fresh cynomolgus hepatocytes / Fresh beagle hepatocytes
↑ Fresh mouse hepatocytes / Fresh rat hepatocytes
Human Cryopreserved hepatocytes
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