Hepatocytes

Hepatocytes

Primary hepatocytes are widely used as the gold-standard in-vitro liver model for biological, pharmacological and toxicological studies in drug discovery and development

Biopredic International provides a wide range of high quality fresh and cryopreserved hepatocytes, obtained from human and several animal species, to meet the specific needs of our customers in view of many in-vitro applications.

Key advantages of hepatocytes produced at Biopredic International

  • A regular supply of fresh human and animal primary hepatocytes, i.e. 2 isolations per week from multiple species (rat, mouse, dog and monkey)
  • A wide range of fresh and cryopreserved hepatocytes, offering flexible choices
  • Larger batch sizes of cryopreserved hepatocytes and the possibility to scale up (i.e. pooled donors)
  • Pre-qualified cryopreserved human and animal hepatocytes allowing in-vitro protocols to meet your specific application requirements
  • Full characterization data available for each product lot, including Phase I /II drug-metabolizing enzyme activities 
  • A professional storage and delivery of fresh plated hepatocytes with Biopredic’s patent-pending Sealovac™ Packaging Technology (guaranteed for a maximum of 3 days)
  • A complete Certificate of Analysis available for all products, including donor information, quality control values and specifications, as well as serological and sterility results
  • Custom preparations according to your specifications.

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Fresh Hepatocytes

Freshly isolated hepatocytes are widely accepted as a superior in-vitro model for evaluating the in-vitro hepatic metabolism and toxicity of test compounds because they more closely reflect the in-vivo situation, when compared with other models.

Biopredic International has built up a well-organized supply network which guarantees the regular delivery of human liver resects (after partial hepatectomy or from human whole livers rejected for liver transplantation) and animal livers. High quality fresh human and animal hepatocytes are isolated and then fully characterized.


Fresh human hepatocytes products include

  • Hepatocytes suspensions suitable for short-term metabolism studies (up to 4 hours) and
  • Plated (monolayer) hepatocytes cultures for longer-term metabolism studies (up to 3 days).

Fresh human hepatocytes in suspension

Fresh plated human hepatocytes

Fresh Animal Hepatocytes

Biopredic International provides a wide range of fresh animal hepatocytes obtained from a variety of species: rat, mouse, hamster, rabbit, cynomolgus monkey, dog, minipig and other species (available on demand).

Fresh animal hepatocytes can be prepared from either single animal liver donor (such as mouse, rat, dog, monkey, rabbit or hamster) or pooled from several animal donors (mouse, rat or rabbit) according to our production schedule.

All rodent hepatocytes are isolated from animals housed in our animal facility which is managed in strict compliance with the Directive 2010/63/EU of the European Parliament and of the Council.
Hepatocytes of other animal species are isolated from the liver tissues collected following approved protocols and respecting all ethical and legal requirements.


Fresh animal hepatocytes products include

  • Hepatocytes suspensions
  • Plated (monolayer) hepatocytes cultures

Fresh Animal Hepatocytes in suspension

Fresh Plated Animal Hepatocytes

CRYOPRESERVED HEPATOCYTES

Biopredic International has more than 20 years in-house experience of cryopreserving human and animal hepatocytes.

Biopredic offers hepatocytes in suspension (Grade S) or plateable.
Plateable hepatocytes are offered in different grades:

  • Cryoplateable Human Hepatocytes (Grade P)
  • Cryoplateable and inducible Human Hepatocytes (Grade I)
  • Cryoplateable & easy-to-use Hepatocytes (Grade NS for “no-spin required”)
  • Cryoplateable & sandwich culture hepatocytes

Biopredic International is also the sole European distributor of cryopreserved hepatocytes produced by Triangle Research Labs (TRL), offering a wider supply of human hepatocytes.
Every lot of human cryopreserved hepatocytes from TRL is fully characterized for viability/stability, cell yield, attachment efficiency (and optimal seeding density), monolayer confluency, Phase I and II drug enzyme activities, induction potential, transporter activity, and 14 relevant SNPs. 

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Hepatocytes - Quick links

Fresh hepatocytes

Cryopreserved hepatocytes

  • Cryopreserved human hepatocytes in suspension
  • Cryoplateable human hepatocytes
  • Cryopreserved animal hepatocytes in suspension
  • Cryoplateable animal hepatocytes

Reagents for hepatocytes

Hepatocytes_sandwich_collagene_48hFresh plated hepatocytes
↑ Hepatocytes in collagen sandwich after 48h/ Fresh plated hepatocytes
Sealovac technology
↑ Sealovac™ Technology for fresh plated hepatocytes
fresh_cynomolgus_hepatocytesfresh_beagle_hepatocyte
↑ Fresh cynomolgus hepatocytes / Fresh beagle hepatocytes
fresh_mouse_hepatocytesFresh_rat_hepatocytes
↑ Fresh mouse hepatocytes / Fresh rat hepatocytes
Human Cryopreserved hepatocytes
↑ Human cryopreserved hepatocytes